IBC’s therapeutic approach
IBC-Ab002, an anti-PD-L1 monoclonal antibody tailored for treating Alzheimer’s disease.
AAIC Poster presentation, July 29, 2020 Read More
Breaking immune tolerance by targeting Foxp3(+) regulatory T cells mitigates Alzheimer's disease pathology.
Nature Communications, August 18, 2015 Read More
PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease.
Nature Medicine, January 18, 2016 Read More
PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model.
Nature Communications, January 28, 2019 Read More
Aging-induced type I interferon response at the choroid plexus negatively affects brain function.
Science. October 3, 2014 Read More
Scientific review articles: immune cell involvement in brain tissue maintenance and repair
A 20-Year Journey from Axonal Injury to Neurodegenerative Diseases and the Prospect of Immunotherapy for Combating Alzheimer's Disease.
Journal of Immunology. January 15, 2020 Read More
Orchestrated leukocyte recruitment to immune-privileged sites:
absolute barriers versus educational gates.
Nature Reviews Immunology. February 25, 2013 Read More
The resolution of neuroinflammation in neurodegeneration:
leukocyte recruitment via the choroid plexus.
The EMBO Journal, December 20, 2013 Read More
Targeting neuro-immune communication in neurodegeneration:
Challenges and opportunities.
Journal of Experimental Medicine, October 9, 2018 Read More
Influenza vaccine combined with moderate-dose PD1 blockade reduces amyloid-β accumulation and improves cognition in APP/PS1 mice.
Brain, Behavior, and Immunity, September 19, 2020 Read More
Immunization with Bacillus Calmette-Guerin (BCG) alleviates neuroinflammation and cognitive deficits in APP/PS1 mice via the
recruitment of inflammation-resolving monocytes to the brain.
Neurobiology of Disease, May 2017 Read More
Bacillus Calmette-Guerin (BCG) therapy lowers the incidence of Alzheimer's disease in bladder cancer patients.
PLOS One, November 7, 2019 Read More
Intraperitoneal injection of IFN-gamma restores microglial autophagy, promotes amyloid-beta clearance and improves cognition in APP/PS1 mice.
Cell Death and Disease, June 8, 2020 Read More
Influenza vaccination in early Alzheimer's disease rescues amyloidosis and ameliorates cognitive deficits in APP/PS1 mice by inhibiting regulatory T cells.
Journal of Neuroinflammation, February 19, 2020 Read More
Hematopoietic CC-chemokine receptor 2 (CCR2) competent cells are protective for the cognitive impairments and amyloid pathology in a transgenic mouse model of Alzheimer's disease.
Molecular Medicine, November 29, 2011 Read More
Scara1 deficiency impairs clearance of soluble amyloid-beta by mononuclear phagocytes and accelerates Alzheimer's-like disease progression.
Nature Communications, June 25, 2013 Read More
Therapeutic effects of glatiramer acetate and grafted CD115+ monocytes in a mouse model of Alzheimer's disease.
Brain, August 2015 Read More
Peripherally derived macrophages modulate microglial function to reduce inflammation after CNS injury.
PLOS Biology, October 17, 2018 Read More
Exploiting microglial and peripheral immune cell crosstalk to treat Alzheimer's disease.
Journal of Neuroinflammation, April 5, 2019 Read More
Activated Bone Marrow-Derived Macrophages Eradicate Alzheimer's-Related Abeta42 Oligomers and Protect Synapses.
Frontiers in Immunology, January 31, 2020 Read More
The adaptive immune system restrains Alzheimer’s disease pathogenesis by modulating microglial function.
Proceedings of the National Academy of Sciences, March 1, 2016 Read More
Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer’s disease.
Neuron, February 16, 2006 Read More
Attenuation of AD-like neuropathology by harnessing peripheral immune cells: Local elevation of IL-10 and MMP-9.
Journal of Neurochemistry, November 20, 2009 Read More