Our Science
Publications
Selected publications
Harnessing Peripheral Immunity in Early Alzheimer’s Disease: Safety and Tolerability of IBC-Ab002 in an ongoing Phase 1b Clinical Trial
CTAD Poster presentation, 2024
IBC-Ab002 Fc modifications for fast clearance are associated with advantageous safety profile
AAIC Poster presentation, 2023
PD-L1 blockade therapeutic effect in Tau P301S (line PS19) mouse model of tauopathy
AAIC Poster presentation, 2023
Key role of the CCR2-CCL2 axis in disease modification in a mouse model of tauopathy
Molecular Neurodegeneration, 2021
Alzheimer’s disease modification mediated by bone marrow-derived macrophages via a TREM2-independent pathway in mouse model of amyloidosis
Nature Aging, 2021
IBC-Ab002, an anti-PD-L1 monoclonal antibody tailored for treating Alzheimer’s disease
AAIC Poster presentation, 2020
A 20-Year Journey from Axonal Injury to Neurodegenerative Diseases and the Prospect of Immunotherapy for Combating Alzheimer’s Disease
Journal of Immunology, 2020
PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model
Nature Communications, 2019
Targeting neuro-immune communication in neurodegeneration: Challenges and opportunities
Journal of Experimental Medicine, 2018
PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer’s disease
Nature Medicine, 2016
Breaking immune tolerance by targeting Foxp3(+) regulatory T cells mitigates Alzheimer’s disease pathology.
Nature Communications, 2015
Aging-induced type I interferon response at the choroid plexus negatively affects brain function.
Science, 2014
The resolution of neuroinflammation in neurodegeneration: leukocyte recruitment via the choroid plexus
The EMBO Journal, 2013
Related publications by other research groups
Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy
Nature, 2023
Administration of anti‑ERMAP antibody ameliorates Alzheimer’s disease in mice
Journal of Neuroinflammation, 2021
Programmed Cell Death Protein 1 Blockade Reduces Glycogen Synthase Kinase 3β Activity and Tau Hyperphosphorylation in Alzheimer’s Disease Mouse Models
Frontiers in Cell and Developmental Biology, 2021
Influenza vaccine combined with moderate-dose PD1 blockade reduces amyloid-β accumulation and improves cognition in APP/PS1 mice
Brain, Behavior, and Immunity, 2020
