Our Science


Selected publications

IBC-Ab002 Fc modifications for fast clearance are associated with advantageous safety profile

AAIC Poster presentation, 2023

PD-L1 blockade therapeutic effect in Tau P301S (line PS19) mouse model of tauopathy

AAIC Poster presentation, 2023

Transforming the understanding of brain immunity

Science, 2023

Key role of the CCR2-CCL2 axis in disease modification in a mouse model of tauopathy

Molecular Neurodegeneration, 2021

Alzheimer’s disease modification mediated by bone marrow-derived macrophages via a TREM2-independent pathway in mouse model of amyloidosis

Nature Aging, 2021

IBC-Ab002, an anti-PD-L1 monoclonal antibody tailored for treating Alzheimer’s disease

AAIC Poster presentation, 2020

A 20-Year Journey from Axonal Injury to Neurodegenerative Diseases and the Prospect of Immunotherapy for Combating Alzheimer’s Disease

Journal of Immunology, 2020

PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model

Nature Communications, 2019

Targeting neuro-immune communication in neurodegeneration: Challenges and opportunities

Journal of Experimental Medicine, 2018

PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer’s disease

Nature Medicine, 2016

Breaking immune tolerance by targeting Foxp3(+) regulatory T cells mitigates Alzheimer’s disease pathology.

Nature Communications, 2015

Aging-induced type I interferon response at the choroid plexus negatively affects brain function.

Science, 2014

The resolution of neuroinflammation in neurodegeneration: leukocyte recruitment via the choroid plexus

The EMBO Journal, 2013

Related publications by other research groups

Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy

Nature, 2023

Administration of anti‑ERMAP antibody ameliorates Alzheimer’s disease in mice

Journal of Neuroinflammation, 2021

Programmed Cell Death Protein 1 Blockade Reduces Glycogen Synthase Kinase 3β Activity and Tau Hyperphosphorylation in Alzheimer’s Disease Mouse Models

Frontiers in Cell and Developmental Biology, 2021

Influenza vaccine combined with moderate-dose PD1 blockade reduces amyloid-β accumulation and improves cognition in APP/PS1 mice

Brain, Behavior, and Immunity, 2020